Conan The Bacterium's Superpower: Resisting Radiation

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What microorganism can survive extreme radiation?

Jessica Young 0:33
All that on this episode of Shortwave, the science podcast from NPR. OK, Ari, where do you want to start?
Unknown 0:53
I'm intrigued that there is a radiation resistant microorganism, this like super, super tiny little thing. What is it?

How did Conan the Bacterium earn its nickname?

Oh, totally. OK, so formally, this bacteria is called Deinococcus reuterans. It was discovered back in the 1950s and has been long known to withstand radiation doses thousands of times higher than what it would take to kill a human or any other living thing.
Jessica Young 1:15
Which is why scientists have given it this funny nickname, Conan the Bacterium, a resilient superhero of the microbial world.

What is the secret behind Conan's radiation resistance?

Unknown 1:22
Do kids today even know what Conan the Barbarian is? I feel like that's such a dated reference.
Jessica Young 1:27
True. Email us, kids. Let us know.
Unknown 1:29
I'm assuming scientists have just been dying to find out the secret to this Conan the Bacterium's radiation resistance ever since.
Yeah, definitely. Because the implications could be really huge, like helping protect astronauts from radiation in space or other kinds of medical applications. But over the years, scientists have suspected that the bacteria's radiation shield has probably something to do with these ingredients inside of its cells, like phosphate, manganese, and peptides.
Ari Shapiro 1:57
question has been, how are these things coming together? The magic of how these things come together has been a mystery.
Jessica Young 2:05
This is Michael Daly, a professor of pathology at the Uniformed Services University, who has studied the Conan bacteria for decades.
Unknown 2:12
Please tell me he has solved the mystery.
Well, with the help of Brian Hoffman, yes. Brian's a chemist from Northwestern University. And conveniently, he has access to a tool that allows you to see what's happening inside a living cell and study his chemistry. So he and Michael partnered up. And Brian says going into the research.
Brian Hoffman 2:29
I never confessed to Mike at the time. I absolutely believed that the efficacy was just the sum of the pieces.
meaning they would just see as much radiation resistance as there was for each of those parts individually.

What implications does this research have for space travel?

Brian Hoffman 2:45
But it turns out... Oh my God, it is more than the sum of its parts. It's something new that forms when you put the pieces together. which makes it better than one or the other, is that the combination, they interact with each other.
Unknown 2:59
The whole is greater than the sum of its parts. Amazing. Like a scientific actual application of that metaphorical artistic idea.
Jessica Young 3:07
Yeah, look, when combined, these three, phosphate, manganese, and peptides, offer astounding radiation protection. The details about this appear in the Proceedings of the National Academy of Sciences, and Michael says this breakthrough means big things for the future.
Michael Daly 3:21
We now have a much better understanding of the nature of the complex and how it is formed, which means we can now try and think of ways of making them better.

How can we combat the loneliness epidemic?

Michael says that he hopes that this can lead to innovations. For example, a medication that astronauts can take to make them more radiation resistant before, you know, long missions to Mars.
Unknown 3:44
Cool. All right, let's move on to the second topic, how to help with the loneliness crisis, which we know affects millions of people in the U.S. of all ages. We've been hearing about it for years. What's new?
Jessica Young 3:54
Yes, we have a very lonely society, and there are a lot of studies out there showing this, including the National Poll on Healthy Aging from the University of Michigan. Now, for six years, the poll gathered household data from older Americans ages 50 to 80 about how lonely they are, loneliness being defined as feeling a lack of companionship.

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