Continuous Renal Replacement Therapy (CRRT) is one of the most important dialysis therapies used in the ICU for critically ill patients with acute kidney injury (AKI), septic shock, metabolic acidosis, and fluid overload. In this complete ICU guide, we cover everything you need to know about CRRT, including: • CRRT basics and core physiology • Indications for CRRT in the ICU • CRRT prescription fundamentals • Effluent dose (20–25 mL/kg/hr) • Ultrafiltration and net fluid removal • Dialysate vs replacement fluid • Transmembrane pressure and sieving coefficient • CVVH (convection-based CRRT) • CVVHD (diffusion-based CRRT) • CVVHDF (combined diffusion + convection) • Full modality comparison • CRRT vs intermittent hemodialysis (iHD) • CRRT vs SLED • When to choose each therapy Core framework: CVVH = convection (flow-driven clearance) CVVHD = diffusion (gradient-driven clearance) CVVHDF = both CRRT = continuous, hemodynamically gentle dialysis ideal for unstable ICU patients. If you work in emergency medicine, critical care, nephrology, or the ICU, this episode provides a clear and practical framework for understanding and prescribing continuous renal replacement therapy. Designed for ICU nurses, residents, fellows, respiratory therapists, advanced practice clinicians, and physicians. Master the mechanism — not just the machine settings. 📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians. Watch the full video version: https://www.youtube.com/@WhiteBoardMedicine Disclaimer: This podcast is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. The information discussed reflects general principles of emergency and critical care medicine and should not replace clinical judgment, institutional protocols, or individualized patient care decisions. Always consult appropriate medical professionals and guidelines when managing patients.

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