Dr. Gabrielle Lyon

speaker

20,330 appearances 51 recordings 13 series first heard Nov 2024 last heard yesterday

Dr. Gabrielle Lyon’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 45 in all, peaking in Jul 2026 with 9.

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The Dr. Gabrielle Lyon Show · Nobody Told You This About Creatine · 27 Aug 2026 podcast

like they have a newborn. podcast-host

And with brain energy, metabolites improving on imaging, which is pretty extraordinary. podcast-host

The evidence base is there, but it's still very early. podcast-host

What about people with depression? podcast-host

They might benefit from creatine as an add on to standard SSRIs. podcast-host

Individual trials show large effect sizes through a meta-analysis, though found only a small to moderate benefit overall. podcast-host

And the evidence quality is low. podcast-host

So hold that thought because there's an important caveat in the contraindications, which there are not many. podcast-host

Aging brains. podcast-host

More broadly, five of six studies in adults over 55 found a positive relationship between creatine and cognition, particularly in memory and attention. podcast-host

And now we've been using creatine in soldiers for a long time. podcast-host

And traumatic brain injury, creatine has shown promise in pediatric TBI outcomes and preclinical models that support neuroprotection across Parkinson's, Huntington's, and ALS. podcast-host

Now, this is early and mechanistic, but I did want to flag the humility here that the direction is certainly. podcast-host

Worth our attention. podcast-host

Now, and most importantly, really the safety profile, because this is where fear mongering and misinformation lives. podcast-host

Now, at three to five grams a day, this is backed by hundreds of peer-reviewed publications. podcast-host

The record is one of the deepest in the supplement literature. podcast-host

The most consistent side effect, and I hear this all the time in our clinic, is weight gain from water retention. podcast-host

Mm-hmm. podcast-host

And friends, it's not fat, it's intracellular water following creatine into the muscle. podcast-host

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