The a16z Show

AI Is Crossing the Frontier of Human Knowledge | Kevin Weil

26 Jun 2026

Contributed by Lukas

Kevin Weil, the previous CPO & Vice President of Science at OpenAI, joins Speedrun to discuss the future of AI, scientific discovery, and startup buil...

Marc Andreessen on AI, Technology, and the Future of Humanity

25 Jun 2026

Contributed by Lukas

Michael Malice sits down with Marc Andreessen to discuss artificial intelligence, technological progress, economic growth, and the future of human flo...

What Happens to Design After AI?

24 Jun 2026

Contributed by Lukas

Anish Acharya speaks with Microsoft VP of Design John Maeda and Impeccable founder and CEO Paul Bakaus about how AI is changing the practice of design...

What’s Next for Consumer AI? | Josh Elman Joins a16z

23 Jun 2026

Contributed by Lukas

Anish Acharya sits down with Josh Elman to discuss the future of consumer technology and Josh's decision to join a16z. Over the past two decades, Elma...

Jake Paul & Anti Fund: From Creator to Investor

22 Jun 2026

Contributed by Lukas

Jake Paul and Geoff Woo join the podcast to announce Anti Fund’s new $100 million growth fund and discuss the evolution of their investment strategy...

The New Rules of Media | Marc Andreessen & Ben Horowitz

19 Jun 2026

Contributed by Lukas

Recorded live at the New Media Summit, Marc Andreessen, Ben Horowitz, Erik Torenberg, and Gaby Goldberg discuss how media, communication, and influenc...

The Fintech Playbook for Latin America

17 Jun 2026

Contributed by Lukas

Angela Strange and Gabriel Vásquez speak with Addi founder and CEO Santiago Suárez about building one of Latin America's largest financial platforms...

Jack Altman on Product-Market Fit

16 Jun 2026

Contributed by Lukas

Jack Altman joins Speedrun to discuss product-market fit, customer feedback, hiring, fundraising, and the realities of building an enduring company. D...

AI, Design, and the Power of Open Models

15 Jun 2026

Contributed by Lukas

Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relat...

Samo Burja on Growth, Energy, and AI

12 Jun 2026

Contributed by Lukas

Theo Jaffee speaks with Samo Burja, founder of Bismarck Analysis, about AI, industrial capacity, economic growth, and the institutions that shape civi...

Designing the Physical World with AI

11 Jun 2026

Contributed by Lukas

Erin Price-Wright speaks with Alex Modon, cofounder and CEO at Unlimited Industries, and Davide Asnaghi, CEO at Diode Computers, about how AI is movin...

AI, Growth, and the Future of Healthcare | Anish Acharya & Sachin Jain

10 Jun 2026

Contributed by Lukas

SCAN Health Plan CEO Sachin Jain speaks with a16z General Partner Anish Acharya about AI, healthcare, and what it takes for established organizations ...

Tyler Cowen & Alex Tabarrok on AI, Jobs, and Economic Growth

09 Jun 2026

Contributed by Lukas

Wyatt Thomson of OpenAI speaks with economists Tyler Cowen and Alex Tabarrok about AI, labor markets, and the future of economic growth. The conversat...

Building Search for AI Agents with Exa CEO Will Bryk

06 Jun 2026

Contributed by Lukas

Sarah Wang speaks with Exa cofounder and CEO Will Bryk about building search infrastructure for the AI era. The conversation covers Exa’s origins, w...

AI Agents and the Fight for Customer Data

05 Jun 2026

Contributed by Lukas

Martin Casado speaks with George Fraser, cofounder and CEO of Fivetran, about the future of data infrastructure in the age of AI. The conversation cov...

AI Eats the World? A Reality Check with Benedict Evans

04 Jun 2026

Contributed by Lukas

Erik Torenberg speaks with tech analyst Benedict Evans about the current state of AI, what has changed over the past year, and which questions remain ...

Balaji and Steven Glinert on Network States, Supply Chains, and Allied Coalition Strategy

03 Jun 2026

Contributed by Lukas

Theo Jaffee and Sophia Puccini speak with Balaji Srinivasan and Steven Glinert about the shifting balance of power between nations, networks, and tech...

Steven Sinofsky on Apple at 50, Microsoft, and the Future of Computing

02 Jun 2026

Contributed by Lukas

Theo Jaffee speaks with Steven Sinofsky about Apple’s 50th anniversary and the evolution of personal computing over the last four decades. Drawing o...

Building AI Agents for Enterprise Operations

01 Jun 2026

Contributed by Lukas

Anish Acharya and Olivia Moore speak with Pablo Palafox and Luis Paarup about the challenges of deploying AI agents in operationally complex industrie...

Why $1B Exits are Dead

29 May 2026

Contributed by Lukas

David George, General Partner at a16z, and David Clark, CIO at VenCap, discuss how AI is reshaping venture capital and the technology industry itself....

Stablecoins, AI Agents, and The Future of Global Banking

28 May 2026

Contributed by Lukas

Angela Strange speaks with Dileep Thazhmon, founder and CEO of Jeeves, about building a global financial operating system for enterprises across Latin...

Marc Rowan on Private Markets, Software Repricing, and Capital Allocation

27 May 2026

Contributed by Lukas

In 1990, Marc Rowan walked out of Drexel with his belongings in a cardboard box. Within a year, Apollo was managing $6 billion. David Haber speaks wit...

Robin Hanson on Prediction Markets, Gambling, and the Future of Forecasting

26 May 2026

Contributed by Lukas

Theo Jaffee and Sophia Puccini speak with economist Robin Hanson about prediction markets, gambling, and why he believes speculative markets are one o...

Why AI Isn’t Killing SaaS Yet

25 May 2026

Contributed by Lukas

Originally aired on MTS segment, Monetary Matters, Jack Farley and Max Wiethe speak with Ara Kharazian, Lead Economist at Ramp, about what real busine...

Hugging Face's Clem Delangue on Open Source AI and the LLM Bubble | MTS Live

22 May 2026

Contributed by Lukas

Clem Delangue joins MTS to discuss the global open-source AI landscape, the current large language model bubble, and the future of consumer robotics. ...

How Superhuman Took Over Silicon Valley Email

21 May 2026

Contributed by Lukas

Rahul Vorra is the founder and CEO of Superhuman, the premium email client for power users. He previously built the Gmail plug-in Reportive and sold i...

Marc Andreessen on AI, California, and the Future of America | Joe Rogan

20 May 2026

Contributed by Lukas

Marc Andreessen joins Joe Rogan for a conversation on AI, politics, technology, and the future of American society. They discuss how artificial intell...

Rebuilding The American Shipyard

19 May 2026

Contributed by Lukas

Erin Price-Wright speaks with Michael Duffey and Dino Mavrookas about what it will take to rebuild the American defense industrial base for a new era...

The Plan to Make American Crime Obsolete

18 May 2026

Contributed by Lukas

David Ulevitch speaks with Col. Jeffrey Glover and Rahul Sidhu about how AI, drones, and sensor networks are reshaping public safety and what it takes...

Vitalik Buterin on Human Agency in the AI Era

15 May 2026

Contributed by Lukas

Sophia Dew and Binji Pande speak with Vitalik Buterin about technology, human agency, and how the internet is changing the way people think, build, an...

Ben Horowitz - "Your ONLY job is Right Product, Right Time"

14 May 2026

Contributed by Lukas

Ben Horowitz shares lessons from building and scaling companies, drawing on his experience as a founder and CEO. He explains why a founder’s primary...

Energy, Minerals, and the Physical Stack Behind AI

13 May 2026

Contributed by Lukas

Erin Price-Wright speaks with Turner Caldwell and Drew Baglino about what it will take to close America's critical minerals gap and modernize the powe...

Lloyd Blankfein on Risk, Crisis, and Leadership

12 May 2026

Contributed by Lukas

David Haber speaks with Lloyd Blankfein, former CEO of Goldman Sachs, about leadership, risk, and navigating moments of extreme uncertainty. Drawing o...

Marc Andreessen on Builder Culture in the Age of AI

11 May 2026

Contributed by Lukas

Erik Torenberg speaks with Marc Andreessen about the state of AI, media, and the broader cultural and economic shifts shaping the internet. They discu...

Ben Horowitz on the Next Technology Era

08 May 2026

Contributed by Lukas

David Ulevitch speaks with Ben Horowitz about what it means to lead the technology industry at scale, and the responsibilities that come with it. Foll...

Crypto Fund 5: We Raised $2.2B. Here’s Why.

07 May 2026

Contributed by Lukas

Robert Hackett speaks with the general partners at a16z crypto about the launch of their fifth crypto fund and the current state of the industry. They...

The New Space Race: NASA, Artemis, and the Race to the Moon

06 May 2026

Contributed by Lukas

Morgan Brennan speaks with NASA Administrator Jared Isaacman about the next phase of American space exploration and the urgency behind returning to th...

Building Blackstone, Backing Costco, with Tony James

05 May 2026

Contributed by Lukas

David Haber speaks with Tony James about building enduring firms across multiple eras of finance. From joining DLJ when it was a subscale firm to help...

Sarah Rogers: Free Speech, AI Diplomacy, and What America Owes Its Allies

04 May 2026

Contributed by Lukas

Katherine Boyle speaks with Sarah Rogers, Under Secretary for Public Diplomacy, about the intersection of AI, free speech, and global information syst...

Balaji and Taylor Lorenz on AI and Media

01 May 2026

Contributed by Lukas

Theo Jaffee speaks with Balaji Srinivasan and Taylor Lorenz about how AI is reshaping media, trust, and online communication. Building on prior public...

Workday’s Last Workday? AI and the Future of Enterprise Software

30 Apr 2026

Contributed by Lukas

Elena Burger speaks with Joe Schmidt, partner on the enterprise team at a16z, about the future of enterprise software in the age of AI. Using Workday ...

The Shift in Global Drug Development

29 Apr 2026

Contributed by Lukas

Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise to the top of global clinical trial output. They discuss the regulato...

John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

28 Apr 2026

Contributed by Lukas

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender off...

Ben Horowitz on Venture Capital and AI

27 Apr 2026

Contributed by Lukas

Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven bus...

AI Inside the Enterprise

24 Apr 2026

Contributed by Lukas

Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterpri...

Martin Shkreli on AI, Pharma, and What Actually Matters

23 Apr 2026

Contributed by Lukas

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what a...

Balaji Srinivasan: Prove Correct, Not Just Go Direct

22 Apr 2026

Contributed by Lukas

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transformi...

Marc Andreessen: Monitoring the Situation and the Future of Media

21 Apr 2026

Contributed by Lukas

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), ...

Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

20 Apr 2026

Contributed by Lukas

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how G...

Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

19 Apr 2026

Contributed by Lukas

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rul...

From Models to Mobility: Building Waymo with Dmitri Dolgov

17 Apr 2026

Contributed by Lukas

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant bui...

Technology, Culture, and the Next AI Interface with signüll

16 Apr 2026

Contributed by Lukas

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products...

Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI

15 Apr 2026

Contributed by Lukas

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background...

Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

14 Apr 2026

Contributed by Lukas

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, abo...

Building Agents at Home: Parenting, Work, and Benevolent Neglect

13 Apr 2026

Contributed by Lukas

Katherine Boyle and Sarah Wang speak with Jesse Genet, a self-proclaimed startup founder and family builder, about building 11 AI agents while homesch...

What Running Windows at Microsoft Taught Steven Sinofsky About Apple

10 Apr 2026

Contributed by Lukas

Theo Jaffee speaks with Steven Sinofsky, board partner at a16z and former president of the Windows division at Microsoft, about Apple's 50th anniversa...

Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate

09 Apr 2026

Contributed by Lukas

Eddy Lazzarin speaks with Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic, about whether AI progress can or sh...

The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie

08 Apr 2026

Contributed by Lukas

Erik Torenberg, Steve Sinofsky, and Martin Casado speak to Aaron Levie, CEO at Box, about what happens to enterprise software when agents become the p...

Balaji on Why AI Raises the Cost of Verification

07 Apr 2026

Contributed by Lukas

a16z general partner Erik Torenberg speaks with Balaji Srinivasan, angel investor and entrepreneur, about why AI simultaneously reduces the cost of cr...

Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling

06 Apr 2026

Contributed by Lukas

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why c...

Marc Andreessen on AI Winters and Agent Breakthroughs

03 Apr 2026

Contributed by Lukas

This episode originally aired on the Latent Space Podcast. swyx and Alessio Fanelli speak with Marc Andreessen about the arc of AI from its origins in...

Alex Blania on Proof of Human and Building World's Identity Network

02 Apr 2026

Contributed by Lukas

a16z's Ben Horowitz and Erik Torenberg speak with Alex Blania, cofounder and CEO of Tools for Humanity, World, and cofounder of Merge Labs. World is b...

What Happens When a Public Company Goes All In on AI

01 Apr 2026

Contributed by Lukas

David Haber speaks with Owen Jennings, executive officer and business lead at Block, about how the company rebuilt itself around AI agents, small squa...

How Radiant and Heron Are Rethinking Power Generation and Delivery

31 Mar 2026

Contributed by Lukas

a16z general partners Erin Price-Wright and Erik Torenberg speak with Doug Bernauer, founder and CEO of Radiant, and Drew Baglino, founder and CEO of ...

Marc Andreessen on Evaluating Founders and AI's Consumer Surplus

30 Mar 2026

Contributed by Lukas

This episode originally aired on The Twenty Minute VC with Harry Stebbings. Marc Andreessen explains why learning from past investment mistakes can be...

The SpaceX and Tesla Playbook for Hard Tech Startups

27 Mar 2026

Contributed by Lukas

Erin Price-Wright speaks with Chandler Luzsicza, founder and CEO of Galadyne, and Turner Caldwell, cofounder and CEO of Mariana Minerals, about what t...

Security, Resilience, and the Future of Mobile Infrastructure

26 Mar 2026

Contributed by Lukas

David Ulevitch speaks with Justin Fanelli, CTO of the Navy, and John Doyle, founder and CEO at Cape, about how the Navy is transforming its approach t...

Submarines and the Future of Defense Manufacturing

25 Mar 2026

Contributed by Lukas

David Ulevitch speaks with Chris Power, founder and CEO at Hadrian, and Vice Admiral Robert Gaucher, the Pentagon's first direct reporting portfolio m...

The Missing Power Layer of Modern Warfare

24 Mar 2026

Contributed by Lukas

Erin Price-Wright speaks with Adam Warmoth, founder and CEO of Chariot Defense, and Alex Miller, CTO of the U.S. Army, about the power crisis at the h...

Why Every Satellite Needs Earth | Northwood CEO on a16z

23 Mar 2026

Contributed by Lukas

Bridgit Mendler, Co-founder and CEO of Northwood, joins a16z’s Erik Torenberg to discuss the critical but overlooked bottleneck in space: ground inf...

Inside Palantir: Building Software That Matters with Shyam Sankar

20 Mar 2026

Contributed by Lukas

In this conversation, Shyam Sankar, chief technology officer at Palantir Technologies, discusses his new book Mobilize, his commission in the U.S. Arm...

AI Just Gave You Superpowers — Now What?

19 Mar 2026

Contributed by Lukas

A new paper, “Some Simple Economics of AGI,” is making the rounds—Web3 with a16z we sat down with author Christian Catalini (MIT Crypto Economic...

AI, Supply Chains, and the Future of Economic Power

18 Mar 2026

Contributed by Lukas

Erik Torenberg sits down with Jacob Helberg to discuss AI, manufacturing, supply chains, and the new geopolitics of technology. Drawing on themes from...

What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado

17 Mar 2026

Contributed by Lukas

Vishal Misra returns to explain his latest research on how LLMs actually work under the hood. He walks through experiments showing that transformers u...

AI Startups vs. Big Chatbots — With Olivia Moore

16 Mar 2026

Contributed by Lukas

In this episode, originally aired on Big Technology Podcast, Olivia Moore discusses whether AI startups can compete with the big chatbots, why America...

Marc Andreessen on the Mindset of Great Founders — with David Senra

15 Mar 2026

Contributed by Lukas

Marc Andreessen joins David Senra for a conversation about entrepreneurship, history, and what drives some of the world’s most ambitious builders. I...

Emil Michael: Iran, Anthropic and the Future of AI at the Pentagon

13 Mar 2026

Contributed by Lukas

This conversation with Emil Michael, undersecretary of defense for research and engineering and acting director of the Defense Innovation Unit, was re...

Palantir CEO Alex Karp on the Zero-Sum AI Race

12 Mar 2026

Contributed by Lukas

This conversation with Alex Karp, cofounder and CEO of Palantir, was recorded at the a16z American Dynamism Summit in Washington, D.C. Karp discusses ...

What It Takes to Clear a Million Crimes a Year with Flock Safety's CEO

11 Mar 2026

Contributed by Lukas

In this episode, previously aired on Cheeky Pint, Garrett Langley describes how a stolen gun in his Atlanta neighborhood led him to build Flock Safety...

The Top 100 Gen AI Consumer Apps

10 Mar 2026

Contributed by Lukas

Anish Acharya speaks with Olivia Moore about the latest edition of the a16z Top 100 AI Apps report. They cover why ChatGPT is still 30 times bigger th...

Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity

09 Mar 2026

Contributed by Lukas

Daisy Wolf speaks with Dr. Andrew Huberman, professor of neurobiology and ophthalmology at Stanford University and host of the Huberman Lab podcast. T...

Atlassian CEO on the SaaS Apocalypse, AI Agents & What Comes Next

06 Mar 2026

Contributed by Lukas

Alex Rampell and Erik Torenberg speak with Mike Cannon-Brookes, cofounder and CEO of Atlassian, about how to make sense of the SaaS selloff, why not a...

Ben Thompson: Anthropic, the Pentagon, and the Limits of Private Power

05 Mar 2026

Contributed by Lukas

In this conversation, previously aired on TBPN, John Coogan and Jordi Hays speak with Ben Thompson, founder of Stratechery, about his essay "Anthropic...

Ambience CEO Nikhil Buduma on AI in Clinical Workflows

04 Mar 2026

Contributed by Lukas

a16z general partner Julie Yoo talks with Nikhil Buduma, CEO and cofounder of Ambience Healthcare, to discuss how AI is transforming clinical workflow...

Ben Horowitz On What Makes a Great Founder

03 Mar 2026

Contributed by Lukas

On the show Long Strange Trip, Sequoia Capital partner Brian Halligan speaks with a16z’s Ben Horowitz about what separates great founder CEOs from e...

Chris Dixon: From Quant Trading to Building a16z Crypto

02 Mar 2026

Contributed by Lukas

In this feed drop from the Internet History Podcast, host Brian McCullough speaks with Chris Dixon, general partner at a16z, about his path from 1980s...

a16z's New Media Playbook

27 Feb 2026

Contributed by Lukas

Erik Torenberg, Ben Horowitz, and Marc Andreessen discuss how the media landscape has fundamentally changed and what a16z is doing about it. They cove...

When Giants Don’t Go Public: Inside the $5 Trillion Private Tech Market

26 Feb 2026

Contributed by Lukas

Bloomberg's Odd Lots hosts Joe Weisenthal and Tracy Alloway speak with David George, general partner at a16z and head of the firm's growth fund, about...

Ben Horowitz: RSI, Crypto as AI Money, & Classified Physics

23 Feb 2026

Contributed by Lukas

Moonshots host Peter Diamandis speaks with Ben Horowitz, cofounder and general partner at a16z, alongside regular cohosts Salim Ismail, Dave Blundin, ...

Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding

20 Feb 2026

Contributed by Lukas

Michael Truell, CEO of Cursor, sits down with Patrick Collison, CEO of Stripe and an investor in Anysphere, to talk about Collison's history with Smal...

Capital, Compute, and the Fight for AI Dominance

19 Feb 2026

Contributed by Lukas

a16z's Martin Casado and Sarah Wang join Latent Space hosts Alessio Fanelli and Swyx to discuss what makes this AI investment cycle unlike anything in...

From Copilots to Agents: Rebuilding the Company Around AI

18 Feb 2026

Contributed by Lukas

a16z's Angela Strange and Gabriel Vasquez speak with Carlos García Ottati, founder and CEO of Kavak, about building Latin America's largest online us...

WSJ x a16z: The Next 25 Years of Defense Innovation

17 Feb 2026

Contributed by Lukas

In this episode from WSJ Invest Live, Andy Serwer speaks with Katherine Boyle, general partner at a16z, about the American Dynamism practice she helpe...

Novartis CEO Vasant Narasimhan on Transforming a 250-Year-Old Company

16 Feb 2026

Contributed by Lukas

a16z general partner Jorge Conde talks with Vasant Narasimhan, CEO of Novartis International, about transforming a 250-year-old conglomerate into a pu...

Balaji and Dan Wang: The Engineering State vs Lawyerly State

13 Feb 2026

Contributed by Lukas

Balaji Srinivasan speaks with Dan Wang, author of Breakneck, about China's industrial rise, America's competing strengths in software and finance, and...

Anish Acharya: Is SaaS Dead in a World of AI?

12 Feb 2026

Contributed by Lukas

In this episode from 20VC, Harry Stebbings talks with Anish Acharya, general partner at a16z, about the future of SaaS in an AI world. Anish argues th...

How Magic Johnson Built a Billion-Dollar Portfolio in 30 Years

11 Feb 2026

Contributed by Lukas

a16z’s Chris Lyons speaks with Earvin "Magic" Johnson about his 30-year journey from athlete to billionaire businessman. They cover the art of deal-...

Marc Andreessen: Who Runs the World’s AI?

10 Feb 2026

Contributed by Lukas

Cisco president and CPO Jeetu Patel speaks with a16z cofounder Marc Andreessen about why AI may finally break a 50-year productivity slump—and what'...

The State of Markets

09 Feb 2026

Contributed by Lukas

a16z Head of Investor Relations Jen Kha speaks with general partner David George about the state of AI and private technology markets. David shares da...

Balaji & Benedict Evans: When Tech Breaks Industries

06 Feb 2026

Contributed by Lukas

This episode originally appeared on the Network State Podcast. Balaji Srinivasan and Benedict Evans sit down in Singapore for a wide-ranging conversat...