Dave Solo Pod: The Original Smart Drug Masterclass : 1518
episode
The Human Upgrade: Biohacking for Longevity & Performance
46 min
1 speaker
8 chapters
transcribed 1 month ago
Transcript
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Transcript generated automatically by AI and may contain errors.
What is the origin story of piracetam and why did it create the term “nootropic”?
Picture a molecule so unusual scientists had to invent a new word for it. Something that was invented back in the 60s, but no one knew about it. This molecule got me through my career in Silicon Valley and through Wharton Business School, even though no one else was using it. 60 years later, people still take it, including me, for memory, for focus, for creativity, and for mental endurance. And it isn't very potent by way. Definitely not a stimulant, so you have to take a good amount of it. In fact, the typical dosing is between about one and a half and up to five grams per day in divided doses. Because it's the most studied, is the safest. People who've had stroke or dementia, neurologists are using it, rehab physicians, air traffic controllers, and anyone who's got an aging brain and wants it to keep working.
It's not a sedative. It's not a classic stimulant. It doesn't flood your dopamine. It doesn't increase your heart rate. And it seems to subtly change how your brain learns. And that molecule is called You're listening to the human upgrade with Dave Asprey. Every week someone asks me, what's the best peptide? There isn't one. Peptides are signals. Different peptides send different instructions to your body. Some affect metabolism, some are for tissue repair, others influence your brain, recovery, or aging pathways. The right peptide depends on what you're trying to change and what the research shows. My new peptide guide explains what the major peptides do, where the evidence is strong, and what to know if you're just getting started.
Whether you're a Peptide veteran or a total newbie, there's something for you. Download it free at daveasprey.comslash peptide dash guide. Picture a molecule so unusual scientists had to invent a new word for it. Something that was invented back in the 60s, but no one knew about it. While this molecule Got me through my career in Silicon Valley and through Wharton Business School, even though no one else was using it. It's not a sedative, it's not a classic stimulant, it doesn't flood your dopamine, it doesn't increase your heart rate, and it seems to subtly change how your brain learns and how it adapts and how it recovers. It's neuroprotective even. And that molecule is called paracetam. It is the original.
Original nootropic, and it is the single molecule that launched the smart drug movement. Sixty years later. People still take it, including me, for memory, for focus, for creativity, and for mental endurance. And there's a really weird paradox. Decades of data. But the community of biohackers out there still splits into true believers versus total skeptics. But after 60 years, there's plenty of data to say the skeptics may not feel it themselves, but that there's something going on. So there's a better question than do RAS attempts work. Work. It's what kind of brain do they work in? And when? And what do they actually change in the brain? And where are the claims a little too big? Well there's a little story as we get into paracetam.
I ordered my first box of paracetam made by Sandoz Pharmaceuticals in Europe back in the late nineties because my brain was cooked. And I eagerly opened the box and I took it and took it. Every day for a week. And I thought to myself, I just wasted a lot of money, nothing happened. So I stopped. And the day I stopped, I noticed I was having a hard time remembering things. I was grasping for words. And I realized, wow, all week when I was on Paracetam, my brain just flowed. It was effortless. So a lot of people, when you take a subtle nootropic like this, because it's not ampi, you just feel more like yourself. Unless you have cultivated a lot of inner awareness. You're not gonna notice. But you'll notice the lack of it because when things are smooth, they're smooth.
When they're just a little rougher, You notice the lack of smoothness, but you might not notice the improvement right away. I've been on Something in the Racetam family almost every single day for 25 years. And it's one of the reasons that I can be the leader of the biohacking movement with hate companies.
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Chapters
8 chapters
1
What is the origin story of piracetam and why did it create the term “nootropic”?
0:00–5:14
2
How do racetams change acetylcholine, glutamate and AMPA signaling without acting as stimulants?
5:14–11:04
3
What role do membrane fluidity and micro‑circulation play in racetam‑driven brain health?
11:04–15:59
4
How should I dose piracetam, aniracetam, oxiracetam, pramiracetam and phenylpiracetam for different goals?
15:59–21:53
5
Who benefits most from each racetam – aging brains, stroke recovery, athletes, frequent flyers?
21:53–27:06
6
What are the safest ways to stack racetams with choline donors, caffeine, modafinil or other supplements?
27:06–32:29
7
Why are racetams hard to find in the US and what should I look for to avoid counterfeit products?
32:29–37:51
8
What does a beginner’s starter protocol look like and how can I measure if the racetam is working for me?
37:51–46:10
Speakers
1 identifiedMore from The Human Upgrade: Biohacking for Longevity & Performance
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