Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more... : 1515
episode
The Human Upgrade: Biohacking for Longevity & Performance
15 min
1 speaker
3 chapters
transcribed 1 month ago
Transcript
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I'm Dave Asprey. That's Dave Spell D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go. How many nights have you stared at the ceiling, counting the hours until morning? Maybe you tried a sleep supplement, but it knocked you out and left you groggy, like you traded one problem for another. Poor sleep doesn't just make you tired, it kills your performance, slows your brain down, and speeds up aging. Kill Switch from Switch Supplements solves that problem. It works with your biology instead of against it. It contains five. Five gut-friendly, extensively researched ingredients like GABA, magnesium glycinate, and tart cherry extract to help you fall asleep naturally, stay asleep, and wake up clear.
And it's in the form of a delicious, sugar-free, no BS hot cocoa drink. Sleep tracking data proves how well it works. People consistently hit 90-plus sleep scores and more than double their REM sleep in only three days. With KillSwitch. If you're ready for the best sleep of your life, order now at switchsupplements.com and use code DAVE for 20% off. If you don't sleep better, you get your money back. KillSwitch works with your biology. Your body does the rest. Every breakthrough in human performance comes down to one thing, just changing your state. And right now, the science and the technology and the ancient practices are converging faster than you realize. For 50 years, bad policy and stigma blocked scientific researchers from studying some of the most powerful tools for the human brain.
And that just changed. This October, the researchers, the clinicians, the guys, and pioneers in consciousness tech and psychedelics. Are all going to be under one roof in Austin, and you can be there too with me. For the first time ever, I'm hosting and operating Beyond Wonderland. Two full days where you'll learn the science and the practice of changing your state, and you'll get to talk to the researchers doing it. You'll learn how these tools unlock a version of yourself you didn't know existed. You'll find talks about altered states with or without the psychedelics, a tech haul where you can try the tools yourself, right? Checkout sessions, breath works, ceremony, integration circles, and more. This field is moving really fast, and the people who are here in Austin on October 13th and 14th with me are going to be years ahead of everyone who finds out about this later.
Learn more, get your ticket now at wonderlandconference.com. Researchers took over 2,000 genes associated with longevity and mapped them across the larger network of proteins and signaling pathways in the human body. Then they screened over 6,000 approved drugs to see which ones might push those aging-related networks in a healthier direction. Twenty-one drugs stood out, and one of the most surprising was a drug called oxymetazoline, the active ingredient in nasal sprays like affrine. What the model showed was that oxymetazoline may influence age related changes in inflammation and communication between cells. The predicted pathway ran through a receptor called ACKR3 and connected with major aging related proteins, including NFKB, TP fifty three, and AKT1.
Those proteins are involved in inflammation, cellular stress, metabolism, survival, and repair. We already have thousands of approved compounds with known safety profiles. Screening them against aging pathways is faster and less expensive than inventing every molecule from scratch. Aspirin also performed well on the screen, which makes sense given its long history in cardiovascular and inflammation research. But even aspirin, of course, has risks. Oxymetazoline is not something you want to start using chronically. It constricts blood vessels and regular nasal use can cause severe rebound congestion. So please do your own research with this news. This one might surprise you, longtime listeners. A new review looked at more than 350 studies of protein-restricted diets across animals and humans.
In multiple animal species, mice, rats, flies, fish, eating less protein was consistently associated with longer life and better metabolic health.
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Chapters
3 chaptersSpeakers
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