Diet Soda Brain Aging, Hidden Heart Attack Risk, New Cholesterol Pill, Lettuce Recall, and more... : 1507
episode
The Human Upgrade: Biohacking for Longevity & Performance
16 min
1 speaker
8 chapters
transcribed 1 month ago
Transcript
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Transcript generated automatically by AI and may contain errors.
What is the main topic discussed in this episode?
I'm Dave Asprey. That's Dave Spell D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go. I've been saying this for years. Sleep is the single highest return on investment in your longevity stack. Not your morning routine, not your supplements, sleep. And most high performers are still treating it like an afterthought. What I keep seeing in high performers is a stress and nervous system problem. Cortisol stays elevated, GABA signaling gets suppressed. Your brain keeps running long after your body is done. No amount of Intention fixes that. That is exactly what I built quiet mode from Subgrade Labs to address. Seven clinically studied ingredients across five biological pathways to calm your nervous system, bring your cortisol load down, and support the deep, restorative sleep your biology was designed for.
No melatonin, no dependency, no groggy morning. Two capsules during the day to take the edge off, four before bed to actually sleep. Your brain sharper, your recovery faster, every other supplement finally doing what it's supposed to, because your sleep is no longer the weak link. This is the piece most people are missing. Fix it, and everything else changes. That is quiet mode. Shop quiet mode at shopsupgrade labs.com and use code DavePod at checkout for 15% off. We'll start with this one.
How do artificial sweeteners accelerate brain aging and memory loss?
Researchers in Brazil followed almost thirteen thousand people for eight years and tracked how much artificial sweetener they were eating, stuff like aspartame, saccharin, ace K, and even the ones marketed as natural like erythritol and xylitol. The people eating the most, and we're talking about roughly one can of diet soda's worth a day, showed cognitive decline 62% faster than the people eating the least. That's about a year and a half of extra brain aging from one can of soda a down. I've said for years that if something tastes sweet but delivers zero calories, your body doesn't just shrug it off, it reacts to the mismatch. There are three ways this probably plays out in real biology. It disrupts the gut microbiome, it messes with glucose and insulin signaling even without calories hitting your bloodstream.
And there's growing evidence some of these compounds hit neurons directly. Any one of those pathways alone would worry me over decades of daily exposure. And this study only tracked eight years, so extrapolate that forward. The one detail worth watching instead of dismissing is the sweetener tagatose, the only one out of seven that showed no effect here. And I want more research before anyone starts marketing it as the safe one. My own stance hasn't changed. If I want something sweet, I reach for a small amount of allulose, or I skip it, because I'm not trading a daily diet soda for a year and a half of my brain. If diet soda or artificially sweetened yogurt is a daily habit for you, swap it out this week and watch how fast your cravings reset.
This comes out of the Scott Hart trial, a well-known UK dataset of over 1,700 people who got coronary CT angiograms for chest pain over 10 years.
Why does muscle fat (myosteatosis) on coronary CT predict heart attacks better than calcium scores?
Researchers ran an AI model called total segmentator against those GANs, and instead of just reading the arteries, they mapped twenty five different structures in the upper body, muscle, bone, organs, fat, all of it. What they were quantifying is something with an actual name, myosteatosis, fat infiltrating directly into skeletal muscle tissue, measured by how much X ray the muscle. Muscle absorbs. Dense lean muscle reads bright. Fat marbled muscle reads dark. 10 points brighter on that scale, and you get 31% lower heart attack risk and 39% lower all-cause mortality over the next decade. Here's the part that actually matters. This predicted risk independent of coronary calcium score. Calcium scoring is the gold standard right now.
It's the number everybody in this audience already gets checked and optimizes around, and myosteatosis added prognostic information on top of it, not instead of it. That tells you calcium score isn't capturing the whole cardiovascular risk picture.
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Chapters
8 chapters
1
What is the main topic discussed in this episode?
0:01–1:33
2
How do artificial sweeteners accelerate brain aging and memory loss?
1:33–3:29
3
Why does muscle fat (myosteatosis) on coronary CT predict heart attacks better than calcium scores?
3:29–4:36
4
What should you know before considering Merck’s new oral PCSK9 inhibitor for LDL reduction?
4:36–7:26
5
Which lettuce products were recalled after the multistate Cyclospora outbreak and why should you avoid pre‑cut greens?
7:26–9:06
6
How does excessive gut‑brain synchronization contribute to anxiety and depression?
9:06–9:58
7
Why does adding a banana ruin the polyphenol power of blueberry smoothies?
9:58–10:45
8
What bio‑hacking predictions does Dave Asprey make for the next five years?
10:45–16:44
Speakers
1 identifiedMore from The Human Upgrade: Biohacking for Longevity & Performance
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