In this episode of The Human Upgrade, Dr. Manoj Doss, a neuroscientist at the University of Texas at Austin Dell Medical School, explores the fascinating intersection of psychedelics, memory, and cognitive enhancement. Drawing from his extensive research, Dr. Doss dives into how psychoactive substances like THC, ketamine, and psychedelics can alter memory formation, consolidation, and retrieval. He challenges the conventional understanding of memory by revealing how these substances might disrupt traditional memory processes while potentially opening new pathways for learning and cognition. You'll discover how different drugs impact your brain's ability to encode and recall information, the surprising effects of psychedelics on semantic and episodic memory, and the role of the hippocampus in shaping our personal narratives. Dr. Doss also delves into the potential benefits and risks of cognitive enhancers like nicotine and modafinil, offering insights into their effects on memory and brain function. Dr. Doss provides a nuanced perspective on the malleability of memory, the ethical implications of memory manipulation, and the complex relationship between trauma, memory, and psychedelics. This episode is essential for anyone interested in the cutting-edge science of memory, the therapeutic potential of psychedelics, and the quest to enhance cognitive performance. Timestamps: 00:00:01 — Opening 00:01:39 — Introduction to Dr. Manoj Doss 00:03:20 — The Impact of Psychedelics on Memory 00:05:50 — The Predictive Processing Framework and Mind Models 00:13:22 — Alcohol and Retrograde Facilitation: Enhancing Memory Post-Study 00:19:00 — Differences Between Episodic and Semantic Memory 00:22:57 — The Role of the Hippocampus in Memory Formation 00:32:35 — Exercise, BDNF, and Memory Enhancement 00:42:29 — The Complex Relationship Between Psychedelics and Neurogenesis 00:52:16 — The Fallibility of Memory and False Memory Formation 01:09:04 — The Influence of Nicotine, Modafinil, and Other Cognitive Enhancers 01:30:34 — Closing Remarks Sponsors: ARMRA | Go to TryARMRA.com and use the code DAVE to get 15% off your first order. Leela Quantum | Head to LeelaQ.com/Dave for 10% off. Resources: Follow Dr. Manoj Doss on Twitter Dave's Linktree: https://linktr.ee/daveasprey Follow Dave on Instagram: @Dave.Asprey Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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“What did the council decide on item 42?” — answered with the speaker and the moment.