Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495
episode
The Human Upgrade: Biohacking for Longevity & Performance
14 min
1 speaker
8 chapters
transcribed 1 month ago
Transcript
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Transcript generated automatically by AI and may contain errors.
How does plasma acetate link gut bacteria to brain health and metabolism?
I'm Dave Asprey. That's Dave Spell D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go. Have you ever promised yourself you would do things differently, only to end up right back in the same pattern? The same relationship, the same habit, the same reaction, the same result. Predictive mind helps explain why. You complete an assessment and then review the results in a one-on-one session. Their brain pattern mapping process reveals the hidden drivers behind your behavior and decision making, so you can finally. See what has been shaping your choices all along. This goes beyond personality tests and self-help advice. Predictive Mind maps the patterns that influence how you react, how you make decisions, and why certain cycles keep repeating in your life.
Once you can see the pattern, you can start changing it. If you've ever felt stuck, frustrated, or confused by your own behavior, check this out. Go to predictivemind.io. And use code DAVE for ten percent off your brain pattern mapping session. We'll start with this one this week. So there's a new study out of Nature Communications that looked at older adults and found something I've been saying for years without the mediation statistics to back it up. They looked at plasma acetic acid, that's acetate, mostly made by your gut microbes when they ferment fiber, and found it's connected to better cholesterol numbers, less body fat, a bigger thalamus, and sharper judgment. The stats show acetate acting as an actual mediator, sitting between your gut bugs and your brain health.
Why are GLP‑1 drugs associated with increased smell and taste disturbances?
The researchers found specifications. Bacteria, Oscillobacter and Coprococcus among them, driving acetate production, and that acetate is doing real work in your bloodstream and apparently in your brain tissue. Now I know some of you are going to hear acetic acid and think, great, time to double my kombucha. Slow down. Kombucha does contain acetic acid, especially the black tea versions, but that's not the same pathway as your colon fermenting fiber and pumping out acetate internally. Drinking vinegar and feeding your own gut bacteria are two different processes. Kombucha has lots of benefits and can taste great, but if you're optimizing for this specific effect, the lever is fiber, not bottles. The upgrade here is simple: feed the bugs that make acetate, resistant starch, and diverse plant fiber.
In this new world of fiber maxing, this story just adds fuel to the fire. Next one's a big data story. Researchers pulled records on over 438,000 people on GLP 1 drugs, matched them against a control group of similar size, and tracked what happened over two years. People on GLP 1s had a 48% higher risk of developing smell or taste disturbances. And when they broke it down, smell problems were up 81% and taste problems were up 52%. We're talking real diagnoses here: anosmia, parosmia where things start smelling rotten that shouldn't, phantom taste that won't go away. I want to be fair to the data. The absolute numbers are still small relative to the total population on these drugs. But this is exactly the kind of signal that gets buried when a drug class is this popular and this profitable.
Everybody's been talking about muscle loss and gut motility with GLP1s. And now we've got a nervous system story nobody saw coming. Which honestly tracks, because GLP1 receptors show up all over the brain, including the olfactory bulb.
What are the global health risks of toxoplasmosis and why should pregnant women worry?
This is the pattern I keep pointing out. We roll out these drugs at massive scale and then spend years discovering what else they touch. If you're on a GLP1 or thinking about it, the upgrade is to actually track your sense of smell and taste over time, not just your weight, and flag any changes to your doctor early instead of assuming it's nothing. This one may be about weighing the risk versus reward. This one's wild for you cat fans. A viewpoint paper is making the case that toxoplasmosis caused by Toxoplasma gondii should officially become a WHO recognized neglected tropical disease.
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Chapters
8 chapters
1
How does plasma acetate link gut bacteria to brain health and metabolism?
0:01–1:52
2
Why are GLP‑1 drugs associated with increased smell and taste disturbances?
1:52–3:56
3
What are the global health risks of toxoplasmosis and why should pregnant women worry?
3:56–5:58
4
How does regular exercise compare to higher income for improving mental health?
5:58–7:42
5
How do individual gut enzymes affect the way we process phytonutrients from produce?
7:42–9:41
6
Which fruits and vegetables should be bought organic according to the Dirty Dozen list?
9:41–11:59
7
What could a $4 billion Unilever bid mean for the quality of Thorne supplements?
11:59–13:33
8
What practical actions can listeners take to apply today’s biohacking insights?
13:33–14:43
Speakers
1 identifiedMore from The Human Upgrade: Biohacking for Longevity & Performance
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