Show notes
Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview Episode Mega-Episode time! Your hormones might be causing symptoms you've been blaming on aging, stress, or your heart. This double interview episode gives you a real look at biohacking from two different angles: cutting-edge longevity science and the lived experience of hormone optimization after 50. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Gabby Reece, an American athletic icon, wellness entrepreneur, and one of the most influential voices in women's health, fitness, and performance. A former professional beach volleyball player who became Nike's first female spokesperson and shoe designer, Gabby set volleyball records at Florida State University that still stand today, and her signature Nike shoe line famously outsold Air Jordan during its release. She has since built a career at the intersection of performance and longevity, co-founding Hamilton House, Laird Superfood (NYSE: LSF), XPT, and HIGHX, and hosting both The Gabby Reece Show and the Proof of Practice podcast alongside leading voices in women's health and evidence-based performance. She is also a New York Times bestselling author. In this episode, Gabby turns the tables and interviews Dave herself, creating a rare two-way conversation between two people deeply immersed in human performance and biohacking. Dave and Gabby dig into how mitochondria function as quantum systems that shape everything from cognitive performance to spiritual perception, why autism can come with genuine neurological superpowers, and what actually happens in the body when hormone levels shift after 40. Gabby shares her personal protocol, including weekly testosterone injections, an estradiol patch, and a compounded hormone cream that most people have never heard of, and explains how correcting her hormones, not her thyroid, resolved a heart arrhythmia doctors initially missed. The conversation also covers Dave's approach to cancer protocols, why he avoids GLP-1 drugs despite their longevity benefits, the peptides he actually uses for mitochondrial renewal, and how cyclical ketosis, fasting, and a carnivore-leaning diet fit into a sustainable performance strategy. They also talk about AI's growing role in personalized longevity research, sleep optimization while traveling, and the supplement and functional medicine protocols Dave relies on daily. You'll Learn: Why Gabby's heart arrhythmia turned out to be a hormone problem, not a cardiac one, and how testosterone fixed it when nothing else worked What "scream cream" actually is, how it works through vasodilation, and why doctors quietly prescribe it during hormone replacement therapy How mitochondria function as quantum systems and why improving their function can sharpen intuition, focus, and perception Why Dave believes autism comes paired with real cognitive advantages once the physical burden of the condition is addressed What Dave would actually do if diagnosed with cancer, from antifungal protocols to high-power infrared light and early detection screening The peptides Dave uses for mitochondrial renewal, including SS31 and lesser-known Russian bioregulators like epitalon and pinealon Why Dave avoids GLP-1 drugs despite believing low doses carry real longevity benefits How cyclical ketosis, fasting windows, and a carnivore-leaning diet support sustainable long-term metabolism Why surrender, not control, was the hardest and most expensive lesson of Dave's career Gabby's advice for raising confident daughters and why she believes success is less about deserving it and more about how you steward it Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Visit www.myvitalc.com/davesfav to unlock Dave’s discount - Fatty15 | You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone therapy, hormone replacement therapy, HRT for women, weekly testosterone injections, scream cream, compounded testosterone cream, vasodilation, AFib hormones, heart arrhythmia, menopause symptoms, thyroid vs testosterone, mitochondria quantum biology, biohacking, Dave Asprey, autism superpowers, cancer protocols, serrapeptase, nattokinase, peptides longevity, cyclical ketosis, carnivore diet, Gabby Reece, longevity for women, anti-aging hormones Resources: • Learn More About The Hamilton House At: https://hamiltonhouse.co/ • Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:52 – Gabby Interviews Dave 02:58 – Fatherhood and Teenagers 12:25 – Autism and Superpowers 17:02 – Quantum Biology & Biohacking 24:03 – Autism Epidemic and Hope 35:01 – Joe Rogan Feud 48:04 – Death, Immortality, Living to 180 56:24 – The Four F's Framework 1:04:55 – Cancer Prevention and Detection 1:18:20 – Travel Biohacking Tips 1:31:46 – Nothing You Can't Hack 1:41:23 – Peptides Deep Dive 1:52:33 – The Human Upgrade Podcast Starts 1:59:35 – Advice at Eighteen 2:10:03 – Fame and Holding Back 2:22:44 – Hormone Replacement Therapy 2:31:31 – Pursuit Over Happiness 2:43:02 – Advice for Tall Women See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.