World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more... : 1483
episode
The Human Upgrade: Biohacking for Longevity & Performance
14 min
1 speaker
3 chapters
transcribed 1 month ago
Transcript
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Transcript generated automatically by AI and may contain errors.
What is the main topic discussed in this episode?
I'm Dave Asprey. That's Dave spelled D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go. Want to know which foods and supplements work best for your body? Viome takes the guesswork out of it. Their full body intelligence test reads your RNA, not your DNA, so you see what's happening in your body right now. While standard labs measure around 100 markers, Viome's AI analyzes over 10,000 active pathways across your gut, oral, and cellular health. Then it Translates that into personalized food and supplement recommendations built for your unique biology. They'll tell you what foods to eat and which ones to avoid. They even create custom supplements and oral care products based on your results.
So what you're getting is what will work for your body, not someone else's. Your results update as your lifestyle changes, so your plan evolves with you. Check it out at Viome.com and And use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. Here's something I've been thinking about. The most dangerous health information isn't the obvious misinformation. It's the stuff that's half right. This week, every story has a version that's technically true and a version that could hurt you. And I want to walk you through the difference. Let's start with the one that actually got my attention this week. A new study in Nature Communications looked at semaglutide, that's the GLP1 drug people know as Ozempic, and found it slowed biological aging markers by 9% on the Dunidin-PACE epigenetic clock.
They also saw improvements on PC grim age, which is tied to all-cause mortality risk, and these effects showed up simultaneously across inflammation, heart, Heart, kidney, liver, and brain markers. Now here's what I want you to understand about why this study is actually bigger than the headlines are making it. The population studied had HIV related metabolic disease, people under severe chronic inflammatory stress. Some people are reading that as a limitation. I read it as a proof of mechanism. What the researchers essentially showed is that when you hit the GLP1 pathway and reduce deep metabolic inflammation, aging clocks move. Not weight, not just blood sugar, aging clocks across multiple. Multiple organ systems at once.
The inflammation aging connection has been the central thesis of everything I've worked on for 20 years, and here it is showing up in a randomized controlled trial with epigenetic data behind it. The FDA approved Bimotrazinol as a permitted sunscreen active ingredient, first new approval in roughly twenty years. It covers both UVA and UVB. It's cleared for adults and kids down to six months, and it's been used safely in Europe and much of the world for years. The FDA cited low skin absorption in its approval. Twenty years. I want to sit with that for a second. Europe has had access to better sunscreen chemistry for two decades. Americans have been using the same formulas in the meantime, some of which have real questions around systemic absorption and hormone disruption that the FDA never fully resolved.
So I'm not going to stand here and applaud a regulatory agency for finally catching up to the rest of the world. On Bimotrazinol specifically, I want to see independent absorption data, not just the manufacturer's submission. Low skin absorption is what every new chemical filter gets marketed as, and then sometimes years later, we find out the picture is more complicated. I've been in the mineral sunscreen camp for a long time. Zinc oxide, titanium dioxide, physical blockers. Partly because the absorption question on chemical filters has never fully satisfied me. But Motrasinol may genuinely be cleaner. The European safety record is meaningful, but I'm not switching my stack based on an FDA press release.
Researchers tested a topical gel made from deoxyribose, the sugar backbone of DNA, on mice with male pattern baldness. Both the deoxyribose gel and minoxidil produced roughly 80 to 90 percent hair regrowth.
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Chapters
3 chaptersSpeakers
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